DDIT3 and gastric cancer: As shown in Figure 5A and 5B, although CHOP was marginally up-regulated by tenovin-6 treatment in all four gastric cancer cell lines, the increased levels were significantly lower than that in control cells treated with thapsigargin, which is a selective inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ - ATPases and widely used as a cellular ER stressor [25], [26].