We demonstrated that tenovin-6 showed potent antitumor activity accompanied by apoptotic cell death in human gastric cancer cells with wt TP53 as well as those with mt TP53. Several specific inhibitors of sirtuins, such as sirtinol, suramin, salermide, and thiobarbiturates, were reported to inhibit cell growth in various types of cancer [29]. The gene discussed is TP53; the disease is gastric cancer.