‘Unknown I’ contained a diverse set of key driver genes such as SGK1, SIK1 and SLC10A6 (sodium metabolism and hypertension), MT2A and TSC22D3 (glucocorticoid signaling), GADD45G, ERRFI1, GPRC5A, and EGFR (cell growth and apoptosis), and CEBPB, CEBPD, and KCNA5 (heart development and function). This evidence concerns the gene SIK1 and hypertensive disorder.