ALK and non-small cell lung carcinoma: The past decade has witnessed the great benefit of the personalized drug therapy in the treatment of non-small-cell lung cancers (NSCLC) [1]–[3], which was designed to target different drug targets, such as KRAS [4], EGFR [5], EML4-ALK [6], the newly found CD74-ROS1 [7], [8], etc. Crizotinib, the latest launched NSCLC drug, was originally designed to competitively inhibit the activity of c-MET [9], whereas has been approved by U.S. Food and Drug Administration (FDA) for the treatment of advanced NSCLC with anaplastic lymphoma kinase (ALK) rearrangements in 2011.