CD8A and viral encephalitis: Indeed, demyelination, the putative hallmark of CHIKV neonatal encephalopathy might also be caused by autoreactive CD8(+)T lymphocytes to clear virally infected target cells, as observed with oligodendrocytes in several mouse models of encephalitis [51], [52], CD8(+) T cells being the most common phenotype of peripheral blood mononuclear cells found in the CSF of cynomolgus macaques, in the only nonhuman primates model challenged by CHIKV [53].