SLC1A1 and glaucoma: In addition, cultured RGCs prepared from EAAC1 KO mice were more vulnerable to oxidative stress.3 Oxidative stress has been proposed to contribute to retinal damage in various eye diseases including glaucoma and age-related macular degeneration.11, 12 Taken together with the downregulation of GLTs and glutathione levels observed in glaucoma patients,13 these mice seem to be useful as the animal models of NTG.