For example, in MS, leukocytes show higher adhesion capacity than normal; in addition, over expression of LFA-1 is also observed, indicating that the LFA-1/ICAM-1 interaction may play a role in the adhesion of leukocytes to brain microvascular endothelial cells (MVEC) and ultimately in the disease pathology [27]. The gene discussed is ICAM1; the disease is myeloid sarcoma.