In fact, MuRF1 and atrogin-1 are transcriptionally activated by FOXO1 and FOXO3 in skeletal muscle [20], [21], and FOXO1 plays a pivotal role in the expressional regulations of MuRF1 and atrogin-1 in various muscle atrophy-related conditions [20]. Here, TRIM63 is linked to muscle atrophy.