HTRA1 and age-related macular degeneration: The impressive impact that genetic information can have on our understanding of disease pathophysiology is highlighted in the recent publication by Yang et al. in which they report that ARMS2/HTRA1 risk alleles contribute to AMD pathogenesis by decreasing the defense capabilities of superoxide dismutase 2 (SOD2) and thereby cause the retinal pigment epithelium to be more susceptibility to oxidative damage [72].