HTRA1 and age-related macular degeneration: This includes the localization of the strongest single genetic effect in AMD on chromosome 10q26 (through positional localization approach) to the region containing ARMS2 and HTRA1 (e.g., [41,42,43,44,45,46,47]), though there is still controversy whether either one or both of these genes contains the causal variant (e.g. [46,47,48,49]).