EGFR and colorectal carcinoma: It has also been suggested that BRAF mutation is a negative prognostic indicator in CRC [18] and a negative predictor of response to EGFR inhibitors, according to results from CRYSTAL, OPUS, and PICCOLO trials [19–21]. BRAF mutation was also associated with shorter progression-free survival (PFS) and overall survival (OS) [22, 23]. KRAS and BRAF mutations are mutually exclusive in CRC [24, 25]; therefore, the National Comprehensive Cancer Network (NCCN) suggests considering BRAF mutation testing when KRAS is wild-type [26].