Previous studies showed that NT-proBNP is detectable in the urine of patients with HF and also in control, healthy subjects.15-17 There was also a good correlation between plasma and urine NT-proBNP concentrations.17 However, there are few studies evaluating urine levels of NT-proBNP and its accuracy in diagnosing CHF.15-22. This evidence concerns the gene NPPB and hydrops fetalis.