A large-scale population-based prospective study found that elevated levels of serum ALT (>30 U/L in men and >19 U/L in women) are associated with liver disease mortality, and that elevated levels of serum GGT (>51 U/L in men and >33 U/L in women) are associated with not only liver disease mortality but also mortality from all causes, malignancy and diabetes [23]. The gene discussed is GPT; the disease is diabetes mellitus.