ERBB2 and breast cancer: The expression of CCR4 by tumor cells has been indicated to be related to the large-cell transformation of the common type of Cutaneous Non-Hodgkin T-cell lymphoma.8 In another study conducted by Lee et al. the overexpression of CCR4 was associated with tumor recurrence and a lower survival in patients with gastric cancer.26 In a study by Li et al. the correlation of CCR4 expression with HER2 expression, tumor recurrence and lymph node, lung and bone metastasis was revealed in breast cancer.