The expression of CCR4 by tumor cells has been indicated to be related to the large-cell transformation of the common type of Cutaneous Non-Hodgkin T-cell lymphoma.8 In another study conducted by Lee et al. the overexpression of CCR4 was associated with tumor recurrence and a lower survival in patients with gastric cancer.26 In a study by Li et al. the correlation of CCR4 expression with HER2 expression, tumor recurrence and lymph node, lung and bone metastasis was revealed in breast cancer. This evidence concerns the gene ERBB2 and metastasis.