The aim of the present study was to investigate the association of 16C/A SNP (reference SNP no. 4359426) in CCL22 gene (i.e. causes a 2-aspartate to 2-alanine substitution in the CCL22 protein), as well as C1014T SNP (reference SNP no. 2228428) in CCR4 (i.e. causes a silent mutation at position 338 in CCR4 protein [Tyrosine residue]) with an increased risk of developing lung cancer. This evidence concerns the gene CCR4 and lung cancer.