CCR4 and gestational trophoblastic neoplasm: C1014T SNP causes a synonymous substitution in 338 Tyrosine of the CCR4 protein; therefore, while it does not affect the function of the protein but it has been suggested to change mRNA stability and further risk of malignancy.18 A study on the Japanese population showed lack of association of C1014T SNP with Atopic Dermatitis18 but in a study by Naeimi et al. this SNP was highly associated with gestational trophoblastic disease suggesting that this genotype can be used as a prognostic marker.25