More recently, different cytokines have been identified with promising characteristics for future cancer immunotherapy.1 The members of Interleukin (IL)-12 family consisting of heterodimeric cytokines including IL-12 and IL-27, are the most potent antitumor cytokines.2-4 IL-27 consists of EBI3 (an IL-12p40 related protein) and p28 (an IL-12p35 related subunit). This evidence concerns the gene IL27 and cancer.