Multivariate logistic regression analysis showed that the CYP2C19 681AA genotype was an independent risk factor for cerebral ischemic stroke (odds ratio (OR) 6.179, 95% confidence interval (CI) 2.285 ~ 16.708; P = 0.000), which were shown in Table 6, and the CYP2C19 681 AA genotype was an independent risk factor for recurrent stroke (OR 2.305, 95% CI 1.121 ~ 4.743; P = 0.023), while CYP2C19 636 AA genotype was not associated with the recurrence of ischemic stroke (P = 0.098). The gene discussed is CYP2C19; the disease is Stroke.