Frequencies of CYP2C19 681AA (16.7% vs. 8.6%; P = 0.036), CYP2C19 636AA (7.0% vs. 2.2%; P = 0.038) genotype, CYP2C19 681A (36.4% vs. 27.6%; P = 0.023) and CYP2C19 636A (17.5% vs. 10.3%; P = 0.010) allele were significantly higher in recurrent stroke group than in the first onset group. This evidence concerns the gene CYP2C19 and stroke disorder.