NEK1 and polycystic kidney disease: Staining with lectins or proteins that have expressions limited to certain tubular subtypes indicate that the polycystic kidney disease in kat2J/Nek1 −/− mice develops from multiple tubular subtypes, including proximal tubules, loops of Henle, and collecting tubules or collecting ducts (Figure 6A, panels c-f), as well as from glomerular epithelial cells (Figure 6A, panel b).