Interestingly, the latter four factors, Apo A-I, VCAM-1, Fibrinogen and vWF, which are found to be decreased after combination treatment, are either expressed by endothelial cells or are present in the blood, hinting that combination therapy has an effect on the tumor vasculature in the PC14PE6-RFP model. The gene discussed is VCAM1; the disease is neoplasm.