Although normalization of glucagon level by resection of the tumor usually results in a rapid disappearance of the skin disorder[12], elevation of serum glucagon levels alone cannot explain all of the skin findings, since hyperglucagonemia occurring in other situations, such as trauma, burns, diabetic ketoacidosis starvation and cirrhosis, does not lead to a typical rash[13]. This evidence concerns the gene GCG and neoplasm.