To address this hypothesis, we genotyped tagging SNPs (tagSNPs) of five TTSP genes, TMPRSS1, TMPRSS2, TMPRSS3, TMPRSS7, and TMPRSS11E, two other serine proteases uPA and PRSS8, and HGF, and investigated their association with breast cancer risk and patient survival. This evidence concerns the gene TMPRSS3 and breast cancer.