HPN and neoplasm: TMPRSS1 SNPs rs12151195 and rs12461158, TMPRSS2 SNPs rs2276205, TMPRSS3 SNP rs3814903, and TMPRSS7 SNP rs2399403 remained significant in the multivariate analysis including age, tumor grade, histological type, tumor size, nodal status, estrogen receptor (ER) status, and HER2 status (P = 0.008, 0.025, 0.040, 0.046, and 0.047, respectively) (Table 2, Fig. 1).