This may explain the association between MUTYH-deficiency and the recessive form of hereditary multiple colorectal adenoma/carcinoma in humans, known as MUTYH-associated familial adenomatous polyposis (MAP), which has the characteristic feature of G to T transversion mutations in the GAA sequence context [33,34]. The gene discussed is MUTYH; the disease is hyperinsulinemic hypoglycemia, familial, 4.