Most of the studies involving T2DM and insulin resistance utilize data from insulin-resistant or diabetic animal models, such as Zucker fatty (ZF) and Zucker diabetic fatty rats (ZDF) [27], high-fat-fed mice [28], muscle IGF-1 receptor–lysine–arginine (MKR) mice [29], [30], and lep/lep mice [31]. This evidence concerns the gene INS and type 2 diabetes mellitus.