AQP4 and brain edema: After finding moderate brain edema in a once-daily adaptation of the Majchrowicz ethanol gavage model, we determined that edema's deterrence with furosemide in that model and in ethanol-binged HEC slice cultures was neuroprotective [11]—as it was with the diuretic, acetazolamide [12], which fortuitously is an AQP4 inhibitor.