TLR2 and cardiovascular disorder: Because TLR2 in the endothelium can be upregulated by disturbed flow in atherogenic regions [35], [14], by HPF in distal pulmonary arteries as shown in this study, and by saturated fatty acids [36], targeting TLR2 may be an exciting prospect for the treatment of certain cardiovascular diseases [37], [38], especially those characterized by large vessel stiffening.