Although the TD condition can inhibit other enzymes, including the two key mitochondrial enzymes PDH and KGDH, thiamine can reportedly abrogate hippocampal neurogenesis inhibition by mitochondrial inhibitors [36], suggesting that thiamine deficiency might negatively regulate hippocampal neurogenesis by altering mitochondrial function in parallel with its effect on TK. Here, PDP1 is linked to Thiamine deficiency.