Considering the link between obesity and T2D, reduced GLP-1 secretion in T2D, progressively diminished GLP-1 secretory response with increasing BMI [12], as well as the fact that high levels of FFAs induce apoptosis in a number of different cell types, we investigated if hyperlipidemia could result in increased apoptosis, and thus reduced GLP-1-positive cell number and GLP-1 secretory capacity - using an in vitro model. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.