GCG and hyperlipidemia: In fact, many of the before mentioned studies investigating effects of fatty acids on GLP-1 secretion have focused on acute effects, and it can be hypothesized that toxic effects of chronic hyperlipidemia and reduced L-cell mass at some stage outweigh the stimulatory effect of the enteral fatty acids on GLP-1 secretion, i.e. exceeding the ability of the remaining L-cells to compensate.