Notably, ATF7IP’s repressive partners MBD1 and SETDB1 have very different knockout phenotypes, namely mild spatial learning defects and autoimmune disease in adult mice lacking Mbd1, and early embryonic lethality at 3.5 to 5.5 days post conception for the Setdb1 deletion [48-50]. This evidence concerns the gene SETDB1 and autoimmune disease.