It should be noted that “high-expression” genotype of TS gene (2R/3R(G), 3R(C)/3R(G) or 3R(G)/3R(G) in opposition to “low-expression” genotype of this gene (2R/2R, 2R/3R(C) or 3RC/3R(C) had strong negative predictive value for NSCLC patients treated with platinum compounds and pemetrexed. This evidence concerns the gene TYMS and non-small cell lung carcinoma.