TNF and Sepsis: In sepsis, acute immunologic response and excessive release of pro-inflammatory cytokines [Interleukin 1(IL-1), Tumor Necrosis Factor α (TNF-α)] trigger target cells (leukocytes, endothelial cells, hepatocytes, lung and intestine epithelium) and induce cytokine, chemokine, ROS and proteolytic enzymes production[13-16].