In accordance with our results supposedly considered as a marker of inflammation in patients with sepsis, however, due to limitations of our study regarding sample size, difficulties in measuring other defensin subtypes with corresponding structure and lack of data on important cytokines like IL-1 and TNF, further studies are necessary in order to clarify HβD2 and other defensin activities and characterization of potential therapeutic or diagnostic targets. The gene discussed is TNF; the disease is Sepsis.