MGMT and pituitary adenocarcinoma: This data was higher than that form reported clinical studies in TMZ treated functioning PA, non-functioning PA and pituitary carcinoma with the remission rate of 75%, 55% and 72% respectively, which can be explained by Bush’s study that not all MGMT low expression PA respond to TMZ although medical therapy with TMZ can be helpful in the management of life-threatening PAs that have failed to respond to conventional treatments [[24]].