Our study detected 190 positive VEGF expression cases in 197 PAs and 58.9% of them are in high expression level, including 60.7% of PRL-secreting PAs, 78.4% FSH-secreting PAs, 51.9% ACTH-secreting PAs and 57.1% non-functioning PAs. The gene discussed is VEGFA; the disease is gonorrhea.