As shown in Figures 5C7 and 5C8, patients with tumours that had low mRNA expression of PTEN and APE1 had the worst survival compared to tumours that had high mRNA expression of PTEN and APE1 in Test set (p=0.000238) as well as in the TCGA cohort (p=0.000003). This evidence concerns the gene PTEN and neoplasm.