Overexpressed c-Myc leads to activation of the DNA-damage-checkpoint response and increased radioresistance of the PKH26+ stem cell-like subpopulation from nasopharyngeal carcinoma, and knockdown of c-Myc significantly increases DNA DSBs induced by irradiation in the PKH26+ stem cell-like cells [50]. Here, MYC is linked to nasopharyngeal carcinoma.