After characterizing the mechanism by which h-Prune induces WNT pathway activation in HEK293, cells chosen because they have an intact WNT network and are responsive to canonical ligands, including Wnt3a [8], we dissected out the function of h-Prune in lung cancer cell lines, confirming the previous results obtained in HEK293 cells. The gene discussed is WNT3A; the disease is lung carcinoma.