Serum concentrations of h-Prune ranged from 98.8 pg/ml to 980 pg/ml (mean, 294.2±191.2 pg/ml) in lung cancer patients and from 19.5 pg/ml to 183.2 pg/ml (mean, 99.3±52.3 pg/ml) in healthy controls. Here, PRUNE1 is linked to lung cancer.