Wnt-3 gene expression in resected NSCLC was statistically associated with high Ki67, low apoptosis, and high expression of c-myc and survivin, and its overexpression was reported promoting tumor progression and poor prognosis in non-small cell lung cancer [32] We have demonstrated here that lung cancer patients had also high serum levels of Wnt3a. This evidence concerns the gene BIRC5 and non-small cell lung carcinoma.