The HED mice showed higher levels of insulin, IGF-1 and leptin in both plasma (Fig. 4Ai, Bi, Ci) and ascites (Fig. 4Aii, Bii, Cii), while adiponectin levels were unchanged compared to RD group (Fig. 4Di and ii). This evidence concerns the gene ADIPOQ and hypohidrotic ectodermal dysplasia.