In present study, MDR results suggested interaction between RGS4_rs2842026-SLC6A3_rs2975226 in schizophrenia patients of LSG and between BDNF_rs7103411-BDNF_rs1491851-SLC6A3_rs40184 in severely ill patients for their inadequate treatment response. Here, RGS4 is linked to schizophrenia.