LCLs were obtained from donors affected with MS [63% females, Age median 38.5 yrs (range 20–59 yrs), of Jewish (50%) and Arab descent (50%), 81% with relapsing remitting MS, and 75% treated with IFN-β, at the time of blood collection]. This evidence concerns the gene IFNB1 and relapsing-remitting multiple sclerosis.