The ERCC1 Cys8092Ala polymorphism has been suggested to independently predict PFS in patients with NPC treated with cisplatin-based chemotherapy; compared with patients carrying the Cys/Cys genotype, those with Cys/Ala or Ala/Ala genotype were shown to have increased risk of disease progression while on such chemotherapy [37]. The gene discussed is ERCC1; the disease is nasopharyngeal carcinoma.