EZH2 and neoplasm: For example, lncRNA high expression in HCC (lncRNA-HEIH) facilitates tumor growth through Enhancer of Zeste Homolog 2 in humans [18]; LncRNA-HULC which is a highly specific up-regulated lncRNA in HCC, envisaged as a novel biomarker because it could be detected in blood of HCC patients [19]; The expression of LncRNA-MALAT-1 up-regulated predicts tumor recurrence of HCC after liver transplantation [20].