In breast cancers, ZER caused G2/M phase cell cycle arrest associated with downregulation of cyclin B1, Ddk1, Cdc25C, and Cdc25B and Bax/Bak-mediated apoptosis in human breast cancer (MDA-MB-231 and MCF-7) cells and retarded growth of MDA-MB-231 xenografts in vivo [76]. This evidence concerns the gene BAK1 and breast carcinoma.