Unlike this protumorigenic activity, there are also growing evidences showing that human MSCs exert antitumorigenic responses in the tumor sites [146, 147] possibly by the inhibition of the Wnt signaling pathway [148, 149] and inhibition of the Akt signaling pathway [150], both important pathways in the tumor development and progression [151, 152]. This evidence concerns the gene AKT1 and neoplasm.