Our data also revealed that the DPP10789 positive tangles and plaque-associated dystrophic neurites are distributed mainly in layers III–V pyramidal cells of the neocortex and CA1 and CA2 pyramidal cells of the hippocampus in AD brains, consistent with the distribution of Kv4.2 and Kv4.3 subunits in brain [34]. This evidence concerns the gene KCND2 and Alzheimer disease.