Mutations in DGC components cause different types of muscular dystrophy; for example, mutations in dystrophin cause Duchenne muscular dystrophy (DMD), while mutations in α-, β-, γ-, or δ-sarcoglycan (SG) cause limb girdle muscular dystrophy (LGMD) [2-4]. The gene discussed is DMD; the disease is limb-girdle muscular dystrophy.