The pathogenic processing of APP into toxic Aβ fragments occurs in cholesterol-enriched membrane domains of the plasma membrane, known as lipid rafts, consistent with the recognized role of cholesterol in AD pathogenesis based upon experimental and epidemiological evidence linking plasma cholesterol levels and AD development (Notkola et al., 1998; Wolozin et al., 2000; Anstey et al., 2008). Here, APP is linked to Alzheimer disease.