However, we noted that the authors did not measure the levels of allergen-specific IgE, and, in general, total IgE concentrations are a relatively crude method of detecting allergic disorders, since normal values do not exclude the presence of allergic disease, particularly to a single allergen, and since elevated levels of total IgE can be found in many patients with no evidence of allergy [23]. The gene discussed is IGHE; the disease is Allergy.