IGFBP3 and acute respiratory distress syndrome: For example, Ménoret A et al. identified cytochrome b5 and cytokeratin 17 as early markers of ALI in a rats model by using the proteomic PF 2D platform [13]; Schnapp et al. analyzed bronchoalveolar lavage fluid (BALF) from three ALI patients by using proteomics and found that the insulin-like growth factor-binding protein-3 (IGFBP-3) concentration was increased in the BALF from ALI patients when compared to normal controls [14].