AKT1 and gastric carcinoma: In stomach carcinoma cell model, an ethanol extract of Rhus verniciflua Stokes significantly inhibited G1 cell cycle progression via p27Kip1 CDKI upregulation and induced mitochondrial apoptosis through the increment of Bax expression, the inhibition of Bcl-2 expression, the release of cytochrome c, and the activation of caspase-3 and caspase-9 cascade, and this mechanism by Rhus verniciflua Stokes was an enhanced inhibition of the PI3K-Akt/PKB survival pathway [11, 13].