KRAS and infection: Next, we investigated whether intracellular HCV-LP could encapsidate replicon RNA and mediate pseudo-infection using a bipartite trans-encapsidation system employing baculovirus transduction [BacC-p7(1b)] of Huh7 cells carrying the culture-adapted FK5.1neo replicon (Krieger et al., 2001) encoding NS3-5B (Fig. 2a).