In a dominant model, statistical association was found between ESRRB expression and rs10132091 genotypes (p = 0.03), between low dental caries experience and rs10132091 genotypes (p = 0.05), and between low ESRRB expression in whole saliva of adults and rs6574293 genotypes (p = 0.04). The gene discussed is ESRRB; the disease is dental caries.