INS and neoplasm: The up-regulated gene with the lowest P-value (P = 5.08E-15) was CPE (carboxypeptidase E), previously reported to correlate with tumor growth and metastasis [23], which is a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin [24].