As NF-κB activation is commonly observed in breast cancers [24,25,49] and UEV1 upregulation is also frequently observed in breast cancer samples [12-14] and in cultured tumor cell lines [4], and is found to be correlated to tumorigenic indicators [2,3], it is conceivable that a certain percentage of breast cancer samples with NF-κB activation is due to elevated UEV1A expression. This evidence concerns the gene UBE2V1 and breast cancer.