To understand the mechanism by which Uev1A promotes metastasis in breast cancer cells, we took into account that Uev1A has been reported to activate NF-κB in HepG2 [19], and that NF-κB regulates the expression of a large number of genes critical for tumorigenesis, inflammation and metastasis [41]. This evidence concerns the gene UBE2V1 and breast carcinoma.