GPT and adenoviridae infectious disease: The temporary elevation of AST and ALT concentrations after patient 3 began 4PB treatment at 200 mg/kg/day was thought to be caused by adenovirus infection and not by any adverse effect of the 4PB therapy, because both markers increased promptly after the adenovirus infection appeared and decreased to the basal levels concurrently with recovery from the infection (Figure 2A).