Results of recent studies indicate that a single intravenous dose of GLN supplementation ameliorated lung and kidney injury and increased survival in a cecal ligation and puncture (CLP)-induced sepsis model by inhibition of the high-mobility group box protein-1 (HMGB-1)-mediated pathway, which was thought to be a late-stage mediator of systemic damage [14, 15]. Here, HMGB1 is linked to Sepsis.